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  • Positive RNP Antibodies?

    I have Positive RNP Antibodies.

    What does this mean in terms of effects to me, my lupus and future effects?

  • #2
    Hey Surfer,

    I have them too. What was your number on your test results?

    How high were they? Sometimes indicative of a MCTD or so I have been told.

    Comment


    • #3
      Hello,

      Yes, they can, IF very high, be indicative of MCTD (Mixed Connective Tissue Disease).

      However, before you panic...the treatment for MCTD would be exactly the same as for lupus and it does not mean that you would develop all the symptoms or overlaps of MCTD.

      Katharine

      Comment


      • #4
        Er and STRESS avoidance is equally important in MCTD as it is in lupus.

        How about thinking about some Tai Chi or yoga or....? that should fit in very well with tree hugging etc. and might do you the world of good

        You know, before lupus I used to drive 2 hours a day on busy autoroutes to go to work. Since I have had to work differently (from home) I have figured out that I have far more chance of living a long life and fully intend to follow my Mum's example of being a fit 70 year old (and older I would think too). She has dermatomyositis (I have polymyositis overlap) and lupus and is doing very well.

        Please stop trying to look for things to worry about. Worry is really not essential for life and is, indeed, very harmful for anyone with an autoimmune disease as it does cause stress.

        Katharine

        Comment


        • #5
          Hi surferboy,

          High RNP antibodies are indicative of Mixed Connective Tissue Disease (same family as Lupus, same treatment), lower numbers are often associated with Lupus.

          In terms of what it means it changes nothing with you really because the disease is what the disease is in each individual. I have no other antibodies besides ANA yet I have have some rather serious organ threatening problems with Lupus.

          Hope this helps,

          love
          Lily

          Comment


          • #6
            I have Raynauds - so would this be classed as MCTD related?

            I looked into MCTD and it seems to be a lot worse than SLE!

            Unfortunately I dont have the results from the RNP test other than the fact that they were positive.

            Although, I believe the Complement C3 & C4 results are also important for CMTD diagnosis. And I do have those:

            C3 = 1.26
            C4 = 0.19

            1 very high and 1 very low.

            Comment


            • #7
              Sorry Surferboy,

              The info I researched did not come out that MCTD was worse than SLE - I think it depends upon each persons severity of each autoimmune illness combined with other factors! Perhaps I'm wrong (ggod chance as I'm no expert!).

              I also have Raynaulds and Sjogerns, so I suppose these overlap with the Lupus but I still have SLE. Alot of people with SLE have other autoimminue illnesses - like diabetes and thyroid aNd RA. There are loads of autoimminue illnesses that one can have unfortunately!

              I'm sure one of the lovely moderators will come along with a better response!

              From what I read SLE still had a higher mortality rate!

              Perhaps you have MCTD and not Lupus - treatment is the same I think!

              Lesley
              Last edited by greenhaggis; 08-14-2008, 07:44 PM.

              Comment


              • #8
                At my lab, those values for c3 and c4 are in the normal range... are you sure they are out of the normal range for your lab? c3 value is very much textbook/in the middle normal and the c4 is low normal but you'd need to be .15 or lower to be out of the normal range.

                MCTD has quite a varied prognosis much like lupus. If scleroderma is the primary disease process, then prognosis for that could be worse than for someone with "mild" lupus. But overall, it is probably very similar to lupus or possibly better.

                Knowing that you are RNP positive may help explain why they wanted the lung function test done, to try to determine if anything is going on with your lungs and to try to rule out MCTD (with a scleroderma component) or get a baseline value on your lung functioning for future reference.

                Right now though, it seems pretty unlikely that you have any sort of scleroderma component as you have not complained of any symptoms that are specific to scleroderma. So don't worry about it.

                Comment


                • #9
                  Originally posted by Maia View Post
                  At my lab, those values for c3 and c4 are in the normal range... are you sure they are out of the normal range for your lab? c3 value is very much textbook/in the middle normal and the c4 is low normal but you'd need to be .15 or lower to be out of the normal range.

                  MCTD has quite a varied prognosis much like lupus. If scleroderma is the primary disease process, then prognosis for that could be worse than for someone with "mild" lupus. But overall, it is probably very similar to lupus or possibly better.

                  Knowing that you are RNP positive may help explain why they wanted the lung function test done, to try to determine if anything is going on with your lungs and to try to rule out MCTD (with a scleroderma component) or get a baseline value on your lung functioning for future reference.

                  Right now though, it seems pretty unlikely that you have any sort of scleroderma component as you have not complained of any symptoms that are specific to scleroderma. So don't worry about it.
                  Gosh your so smart!:wink2:

                  Comment


                  • #10
                    I have Raynauds - so would this be classed as MCTD related?
                    Not necessarily, I and many other here who have Lupus also have Raynauds, it's very common with Lupus.

                    In my book your complement levels are normal too

                    love
                    Lily

                    Comment

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