Compared with the general population, lupus patients are perhaps
twice as likely to suffer from migraine-like headaches.
Many patients also have antiphospholipid antibodies, while others
display Raynaud's phenomenon.
Lupus headache is managed much like conventional migraine, using
painkillers, anti-inflammatories, vasoconstrictors, & sometimes
beta-blockers, or tricyclic antidepressants.
Lupus headache is different to most migraines, since patients may
respond to a 1 week trial of 20-60 milligrams of prednisone daily,
which is rarely useful to migraine sufferers.