Anti-dsDNA | Lupus Forums at The Lupus Site
  1. As you can see we have transferred to new forum software which is much more stable and will eliminate problems that we had with the old software.
    *** To login you will all need to reset your passwords. To do this simply click login (top right) then click the forgot password link. You will receive an email with a link to reset your password. You can then use the forums as normal.
    Dismiss Notice


Discussion in 'Tests and Procedures' started by Bridget22, Apr 6, 2017.

  1. Bridget22

    Bridget22 New Member

    hi everyone

    I have been told I have Lupus and secondary Sjogren's Syndrome. In the past I was positive for ANA (1:640) and anti-dsDNA (around 200-300).

    I'm now 19 weeks pregnant and my Lupus is behaving. I'm under a high risk OB. I'm negative for clotting tests but on aspirin and lovenox injections. I'm negative for La and Ro antibodies.

    Yesterday I saw my rheumatologist and he said my anti-dsDNA is now negative but my ANA is still high and he's questioning whether I do have Lupus and Sjogren's or UCTD. He did say anti-dsDNA goes up and down depending on symptoms and also pregnancy. Regardless he said I'm very high risk and carry on as I was with all the doctors and tests... ugh!

    Does anyone know about this antibody and pregnancy? Could being pregnant just suppress this antibody?

  2. lazylegs

    lazylegs Moderator

    Hi Bridget,

    Your question may be beyond our scope since you are asking about it in regards to pregnancy. In general however the anti-dsDNA can change. Usually it changes with disease activity. Once positive it doesn't usually go negative according to the sources I checked into however it can dip to very low levels if disease activity is low. I am wondering if it is possible to be low enough to be present but be considered negative by the lab. The specialists are really your best resource at this time.

    Take care,
  3. debatat

    debatat Moderator

    Hi, as Lazylegs said the antibodies fluctuate according to disease activity. If you are on meds then have an influence on your bloods. Pregnancy can either bring periods of calm for lupus activity or lupus flares so this would obviously affect bloods.
  4. Bridget22

    Bridget22 New Member

    Thanks lazylegs and debatat

    I'm going to go in to the lab and get my results so I can actually see the numbers because my doctor didn't show me.

    I know things change and become more complicated during pregnancy so perhaps that's why there's the confusion. My rheumatologist said to proceed as if I have Lupus (i.e, stay on the injections, be considered very high risk, come to hospital if I flare and very regular scans and monitoring). Just when he started questioning the diagnosis it made me feel like I was back to square one when I struggled for years to find a doctor to take me seriously.

    Thanks for your help
  5. Michael Garhart

    Michael Garhart New Member

    The result I remember reading about for pregnancies was anti-cardiolipin.

Share This Page