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Anti-Cardiolipin (Anti-Phospholipid)


Normal Range for anti-IgG = 0 - 20 GPL;  Normal Range for anti-IgM = 0 - 10 MPL.

It is the antibody to the cell membrane.  

Found in approx 33% lupus patients, lupus specificity is fair.

Antibodies to cardiolipin have been associated with an incresased incidence of vascular thrombosis, thrombocytopenia and recurrent fetal loss in patients with SLE. Increased in: SLE, some connective tissue diseases, and in Antiphospholipid Syndrome (Hughes Syndrome).

Patients with acute and chronic infections (including syphilis, HIV, Lyme disease) may also have increased anti-cardiolipin antibodies.




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