Hi, my name is Michael and I live in London. I have MCTD and was finally diagnosed positively in 1996 with Sjogren's syndrome, having had it, I believe, since 1984 but no doctors or specialists thought of running the most basic of autoimmune disease tests! I tend to get "flare-ups" twice a year usually from April to July and then again from October to December. As I get older the flare ups become more severe (I am a fit 65 year old). I have recently been put on Plaquenil 200mg daily and since then have been woken every morning with a severe stomach ache. I take the Plaquenil after breakfast in the morning. Both my colon and my stomach have been checked out and are 100% clear of anything. My other daily medications are statins 40mg, ACE inhibitor 4mg and 75mg aspirin all of which I have been taking for years. Has anyone else had a similar problem with Plaquenil presuming of course that that is the cause.