Hello,
Since my diagnosis my ANA has always been positive. It fluctuates a little. Highest was 1:1280 and the lowest 1:604 (which was my last test) I always have a fine speckled pattern, although once they reported "nuclear dots". My ENA shows always a high positive titre of antibodies to U1-RnP (70 kD-ribonuclear protien) this finding in the absence of other ENA-antibodies (SSA, SSB, Jo-1) is a high diagnostic indicator for MCTD (Sharp's syndrome).
Oh sorry, I just noticed you where asking for those who don't yet have a diagnosis. However, in the beginning for me. I was given a diagnosis of MS based on MRI and nerve conduction tests. I think amoungst the hundreds of blood tests that were done at that time was at least once an ANA. It was positive but I don't how high. It was overlooked by everyone, because the MRI was just so much more interesting! When my problems became "more than just neurological" ANA was determined and the diagnosis was changed. Although my Rheumy stills thinks I have maybe MS as well, the Neuro says not likely that the MCTD and Vasculitis explains all of it.
Good luck to you!
Monique:wink2: