[fayyaz1001]

My mother is suffering from SLE and yesterday we made a blood test of Anti-dsDNA which was 36.1 and its normal range is 0-6.0.
What do u say about the activity or level of the disease with these results.Please reply me soon.
Fayyaz Ahmed

 

[Clare.T]

Anti ds DNA levels are associated with disease activity so there might be a worsening of symptoms now, that could indicate better or additional medicationis needed, all depending on her status otherwise ( worsening symptoms) and other test results ( eg urine, SED rate)
(Presuming it has gone up since the last time)

This could be a short term flare but it is a matter of concern.

I hope that is a quick enough answer for you

Please don't think you have found a doctor - this is a patient to patient, family and friends support forum.

All best wishes to your mother - she is fortunate to have someone looking out for her

Clare

 

[fayyaz1001]

At what level is Anti-dsDNA is worse

 

[Clare.T]

It's worse when it is higher than before and well out of normal range.
It also depends on symptoms, as I said before.

How about a thank you ?

Clare

 

[fayyaz1001]

Thanks

Yes i got your point thank you very much but last thing that is 36 level risky or not?

 

[Joandublin]

Hi again

Its hard to say unless, along with her increasing levels, her symptoms are also increasing. For example has she had a urine test done which may show early signs of kidney problems?

In and of itself the anti dsDNA levels can go up and down. Mine are raised also and have been over 200 and yet I have no organ involvement so take heart A sustained period of low dose prednisone has been successful in bringing them nearly back to 'normal' range.

My own Rheumy says that there isnt enough evidence to say that Antidsdna activity correlates with disease activity. I know other rheumatologists say different The important thing is to find out what else, if anything, is going on especially with the kidneys.

By the way, despite my high antidsdna levels I have no kidney involvement and have never shown protein in my urine.

Hope this helps
Joan:rose:

 

[Clare.T]

It is not good to have a very high ds- DNA and not good if it is rising because it suggests the possibility of worsening disease either current or to come.
But the disease is not blood tests alone: it is blood work along with symptoms and the results of other tests as well as how the patient is feeling and maybe visible signs too.

For example if the patient has kidney disease, other tests such as urine and other blood tests could indicate that the kidney involvement is increasing. There might also be visible signs like swelling.

Your mother's specialist should be able to evaluate the situation - presumably he ordered the tests and will be contacting her about the results. If not then you need to see a specialist to ask what exactly the significance might be in her case. and get a reevaluation
If there is no additional cause for further alarm then it might be simply a question of keeping a close eye on the level.

Regards

Clare