Hi again
Its hard to say unless, along with her increasing levels, her symptoms are also increasing. For example has she had a urine test done which may show early signs of kidney problems?
In and of itself the anti dsDNA levels can go up and down. Mine are raised also and have been over 200 and yet I have no organ involvement so take heart

A sustained period of low dose prednisone has been successful in bringing them nearly back to 'normal' range.
My own Rheumy says that there isnt enough evidence to say that Antidsdna activity correlates with disease activity. I know other rheumatologists say different

The important thing is to find out what else, if anything, is going on especially with the kidneys.
By the way, despite my high antidsdna levels I have no kidney involvement and have never shown protein in my urine.
Hope this helps
Joan:rose: