Have had SLE for over ten years, and until recently took only Plaquenil and Advil. Occasionally prednisone to get through a bad spot, but have been using it more regularly due to work demands. Dr. recently put me on methotrexate instead of the pred, and am experiencing muscle, not joint, problems. Calves are swollen and hurt - tender to the touch as well as feeling like I over-exercised or pulled a muscle. Some fluid retention, with pitting in my ankles. Also in my wrists/forearms sometimes. Anyone else experienced these symptoms? Any advice? Ideas? Thanks.