Dapsone success with SCLE
My experience with Dapsone has been wonderful. I have had scle for 50 years. I don't have sle, but the scle is very severe. At times I have had open lesions over about 40% of my skin surface. I have been on placquinille, prednisone, enbrel, quinacrine, immuran, and prograf over the last 14 years. Nothing helped me much untill I tried Dapsone. I improved after only a couple of days, starting at 25mg. That was about a year ago. Now I am on 100mg/day. The open lesions have all healed, the remaining red rash is diminishing or least fading into a light tan shade.
I have eliminated prograff, enbrel, immuran, and placquinille. I am still on quinacrine and have tapered prednisone from typically 10mg/day to 2.5mg/day. I still have joint pain, but I am attributing that to tapering the prednisone.