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Discussion Starter · #1 ·
Hi All,
I had my biopsy today of my tongue. Everything went well and am home. Just a little bit sore but no worries.
I have to go back in two weeks to get the results.
When i was there i asked the doc if the biopsy could add to the bloods for diagnosis of my disease. I did read some suff on the net that said that immunoflouroscence testing can be used on mucosal biopsy to help identify lupus and other connective tissue disease including MCTD and polymyosistis.
This was one of the Links i found.

http://www.dermpathmd.com/cases/dermatopathology_general/Skin immunofluorecence.pdf

The doc said that this biopsy would be unlikely to show any sign of the disease.
Could it be that immunoflourescene may be being used?
The biopsy is being done to diagnose oral luekoplasia that i have which funnily enough started in oct last year when my other symptoms began?
Wouldbe intersted in any comments.

Cassie :)
 

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Hi Cassie,

That's a good link thanks :foryou:

I know little about biopsy in general except what was mentioned there about testing exposed and non exposed skin and actual lesions for Lupus.

The figures quoted for getting a positive result were interesting, stating that unless it was a severe case then unexposed skin was unlikely to yield a result. It all seems a very precise business and needing an expert Dermy to do the actual biopsy and of course someone who knows exactly what they are doing to interpret the result (Dermatopathologist).

The only oral biopsy that I knew of that can count as a criteria for a connective tissue disease was the one of the salivary glands for Sjogren's. That's quite specific but there are other tests with oral biopsy that can point to the presence of a connective tissue disease but not which one it is.

It seems that to help diagnose a particular disease then the biopsy has to be done on a specific site with a specific method according to which disease they are looking for.

Sorry not much help to you :( Good luck with your results :luck:

love
Lily
 

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You got me googling :lol:

Lupus:

Immunopathology
Data concerning direct immunofluorescence in ACLE are sparse. In one study, the results of 5 of 5 (100%) skin biopsies were reported as positive for the lupus band test. The lupus band test refers to the presence of immunoglobulins (Igs) and C3 complement components along the dermal-epidermal junction. All 3 immunoglobulin classes (immunoglobulin G [IgG], immunoglobulin M [IgM], immunoglobulin A [IgA]) and a variety of complement components have been identified at the dermal-epidermal junction. Recent research has shown that 60% of patients with a malar eruption of LE have positive lupus band test results. In nonlesional skin, positive lupus band test results correlate strongly with an aggressive course of systemic disease
http://www.emedicine.com/derm/topic245.htm

Sjogren's:

Histopathologic findings - Abnormal biopsy findings in a minor salivary gland (focus score >2 in an average of 4 lobules, multiple foci of lymphoid inflammation)
http://www.emedicine.com/derm/topic846.htm

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Lily
 

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Discussion Starter · #4 ·
Hi lily,
thanks, i've got a feeling after giving it some thought that as this is a biopsy ordered by an oral surgeon that firstly they probably won't use the immonoflouroscence technique. This is also so because i did not mention other symtoms to him as thought they were related to my thyroid function when i first saw him so they are not using it a sa diagnostic tool for the MCTD.
I don't need any other diagnostic criteria anyhow as full fill loads of the criteria in cluding bloods etc.
I was more interested in whether i might get a surprise in terms of SLE or something else related to MCTD.
Ithink they are dong just a straight forward procedure to illiminnare cancerous or pre cancerous cells and for diagnosis.
I guess if those results are inconclusive then maybe they could go on to use immunoflourescence?

Do you think this makes sense?

Thanks so much.

Cassie :)
 
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