[Lily]

Hi Cassie,

That's a good link thanks :foryou:

I know little about biopsy in general except what was mentioned there about testing exposed and non exposed skin and actual lesions for Lupus.

The figures quoted for getting a positive result were interesting, stating that unless it was a severe case then unexposed skin was unlikely to yield a result. It all seems a very precise business and needing an expert Dermy to do the actual biopsy and of course someone who knows exactly what they are doing to interpret the result (Dermatopathologist).

The only oral biopsy that I knew of that can count as a criteria for a connective tissue disease was the one of the salivary glands for Sjogren's. That's quite specific but there are other tests with oral biopsy that can point to the presence of a connective tissue disease but not which one it is.

It seems that to help diagnose a particular disease then the biopsy has to be done on a specific site with a specific method according to which disease they are looking for.

Sorry not much help to you Good luck with your results :luck:

love
Lily

 

[Lily]

You got me googling :lol:

Lupus:

Immunopathology
Data concerning direct immunofluorescence in ACLE are sparse. In one study, the results of 5 of 5 (100%) skin biopsies were reported as positive for the lupus band test. The lupus band test refers to the presence of immunoglobulins (Igs) and C3 complement components along the dermal-epidermal junction. All 3 immunoglobulin classes (immunoglobulin G [IgG], immunoglobulin M [IgM], immunoglobulin A [IgA]) and a variety of complement components have been identified at the dermal-epidermal junction. Recent research has shown that 60% of patients with a malar eruption of LE have positive lupus band test results. In nonlesional skin, positive lupus band test results correlate strongly with an aggressive course of systemic disease

http://www.emedicine.com/derm/topic245.htm

Sjogren's:

Histopathologic findings - Abnormal biopsy findings in a minor salivary gland (focus score >2 in an average of 4 lobules, multiple foci of lymphoid inflammation)

http://www.emedicine.com/derm/topic846.htm

love
Lily