I've never had all my complement levels tested,just 3&4 but from what I've read,it could be C2 deficiency with me and my brother.If ,however,that would be reflected in theC3 and 4levels,that would rule it out as mine are normal.Just trying to find answers really,
It seems that a deficiency in one system can lead to a deficienct in another, ie genetic low C2 can leasd to low C4 and development of lupus. I couldn't see that normal C3 or C4 could still be found in people with a C2 deficiency - one flows on to the other if I understand it right.
This is the type of question an immunologist could answer (which I'm not:hehe: ). And remember that for almost everything there is an exception to the rule
that's what I thought too.I couldn't understand if C2 was such a common deficiency,why I wasn't tested for it and I came to the same conclusion,that it would have affected the others,but I will ask anyway,
Just found this article,very interesting.If I am reading it correctly,I think it is saying you can have low C2 but normal 3and 4.Hhhhmmmm,might try to get my complement levels measured!
ok,link wouldn't come up,but it was on medscape,article about complement deficiency and smoking.
I got the impression that it is certainly possible to have only C2 deficiency. As it says, it is the most common inherited one. But it also says they were surprised to find a high prevalence of C2/C4 deficiencies.
I would have though that St Tom's would have tested complement, some at least.
I got the impression from other articles that were very technical that various combinations are possible or only single findings, as far as I could make head or tail of them !
Given how common the symptoms seem to be in your family it's well worth investigating. Maybe an immunologist ? That will give your wretched GP something to think about :lol: