DILE Drug induced Lupus Erythematosis

http://www.lupus.org/education/brochures/drug.html

and from the Postgrad Medicine site

QUOTE
Drug-induced lupus
In 1945, the first lupuslike reaction to a medication was reported with sulfasalazine (Azulfidine). Since then, 70 drugs have been implicated as causing or exacerbating SLE. Many of these are listed in table 2. Drug-induced lupus is most frequent in older patients. Men and women are equally at risk. The most common symptoms are fever, fatigue, arthralgia, and serositis.

Table 2. Medications that may cause drug-induced lupus?
Atenolol (Tenormin)
Captopril (Capoten)
Carbamazepine
Chlorpromazine HCl (Thorazine)
Clonidine HCl (Catapres)
Danazol (Danocrine)
Diclofenac (Cataflam, Voltaren)
Disopyramide (Norpace)
Ethosuximide (Zarontin)
Gold compounds
Griseofulvin
Hydralazine HCl (Apresoline)
Ibuprofen
Interferon alfa
Isoniazid (Laniazid, Nydrazid)
Labetalol HCl (Normodyne, Trandate)
Leuprolide acetate (Lupron)
Levodopa (Dopar, Larodopa)
Lithium carbonate
Lovastatin (Mevacor)
Mephenytoin (Mesantoin)
Methyldopa (Aldomet)
Methysergide maleate (Sansert)
Minoxidil (Loniten, Rogaine)
Nalidixic acid (NegGram)
Nitrofurantoin (Furadantin, Macrobid, Macrodantin)
Oral contraceptives
Penicillamine (Cuprimine, Depen)
Penicillin
Phenelzine sulfate (Nardil)
Phenytoin sodium (Dilantin)
Prazosin (Minipress)
Primidone (Mysoline)
Procainamide HCl (Procan, Pronestyl)
Promethazine HCl (Anergan, Phenergan)
Propylthiouracil
Psoralen
Quinidine
Spironolactone (Aldactone)
Streptomycin sulfate
Sulindac (Clinoril)
Sulfasalazine (Azulfidine)
Tetracycline
Thioridazine HCl (Mellaril)
Timolol maleate (Betimol, Timoptic)
Tolazamide (Tolinase)
Tolmetin sodium (Tolectin)
Trimethadione (Tridione) [/b][/quote]

love
Lily

This is what I wondered for a while, too. I was diagnosed with RA first and, frankly, have a textbook case. The labs, X-rays, exam and symptoms are classic RA. But, early on, some of the Lupus indicators were testing positive, too. Rheumy said we'd have to wait and see on Lupus and he put me on mtx. and Plaquenil to cover both diseases.

I haven't taken any of the drugs on the DILE list -- I've never even overdone the Ibuoprofen. When my symptoms first started more than 2 1/2 years ago, I was put on antibiotic therapy for a few months because of "possible Epstein-Barr and possible Lyme disease." It didn't work, obviously, because I had neither disease.

I had done some research on DILE and hoped that maybe the Lupus symptoms and positive tests were temporary. But it's been two years since I took the antibiotics; more Lupus indicators are positive and organ involvement has begun, too. The antibiotics aren't even on the DILE list. I've accepted it's SLE.

But it's quite the quandry, isn't it?

Julie

QUOTE(raggedyann1 @ Dec 23 2005, 09:50 PM) [post=387883]Quoted post[/post]

Michelle,

Asked my rheumy earlier this year if that could have caused the lupus and that perhaps my original RA dx only(had for a short time) was correct and the med caused the lupus.
Karen
[/b][/quote]

Drugs like Remicade and Enbrel tend to be used cautiously because they can cause ds DNA antibodies which is a concern ,although I haven't seen any reference to clinical lupus resulting.

Cheers
Clare
[/quote]
Could you explain this further? I am currently on Remicade and although I get wonderful results for about week, I then end up reacting to the drug (I get my lupus symptoms back, like I'm in a flair). . My rheumi has mentioned that I am becoming "allergic" to it. it concerns me. He is talking about switching me to Enbrel.
Looking back however overall the drugs that I've taken, I now wonder if they hadn't made my lupus symptoms worse since they didn't help me any. My reaction to the last 3 drugs I've taken mimicks what I would call my "lupus". So I wonder really how much of my symptoms over the years was really "lupus" or symptoms that my body produces as a reaction to things it doesn't like.
I am also concernend that since the Remicade has stopped working and he is talking about moving on to Enbrel.....what if I react to that....and then eventually the next drug? Has any one already been down this road? I'm beginning to look at stem cell transplants and that seems like a very scary last alternative but looks like one i'm heading toward.
~Jillian

Another drug to look out for is Levoquin.... I was put on it for a supposid intestinal infection. My lupus kept getting worse and worse, increasing my prednisone didn't help. I couldn't figure out why my "lupus" was getting so bad (I could not get out of bed for several weeks due to severe muscle and joint pain, had fevers, the whole 9 yards of what my flairs are like, except this time, much worse). Finally I developed an anaphalactic reaction about 21 days into the med and after stopping and double dosing with double does of prednisone , it took a good week to get it out of my system. I truely thought I was going to die during this experience. Its one of the most toxic antibiotic out there so be aware whould you ever get prescribed it.
~Jillian

I'm amazed about the drug list

I have never been on any of these drugs but yet have Lupus and RA. My causes from getting RA first was a chemical exsposure that I had that caused one of my lobes in my lungs to be removed. My lungs produse bacteria all the time and so that is what caused the LUPUs and RA according to the doctors.

What bothers me is that my husband has been on Zarotin for about 6 years. Do you all think I should have him go to the doctors and get test done to see if he has the Lupus? I know how bad I suffer with RA and Lupus I would hate for him to go thru this.

Thanks for all the info on the medications and fed back. I have read them all and have to say I'm quite amazed. I'm in the severe stages now of RA and Lupus. A lot is happening to me health wise and I have to say I'm getting down in the dumps. Last week I was told there was nothing they can do about my back and that I would be in a wheel chair with in a year. Lupus and Ra has hit the spine bad destroying nerves and the spine. I'm having a hard time dealing with it.

Alll have a wonderful day and always think positive.

Deanna

Minocycline Induced lupus

Something worth noting if you know a teen who starts having lupus like symtpoms and is on minocycline.

http://www.uklupus.co.uk/mino.html

http://pediatrics.aappublications.org/cgi/content/full/101/5/926

http://www.med.ucla.edu/modules/wfsection/article.php?articleid=39

If the symptoms go when the drug is stopped then it's drug induced but it seems that in a few predisposed people clinical lupus is triggered.

It seems that in some places a warning of the possibility is noted on the packaging. Even if it is rare, there should be a general warning as this is for all side effects howver unlikely.

Clare