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Hi, I would be grateful for information on drug interaction as my sister-in-law has been diagnosed with lupus and she already has epilepsy. Her GP says that he cannot treat her lupus as it would interfere with her Epilim used for control of her epilepsy. I would be grateful on her behalf for any help.
Thanks
John
 

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Hello John and welcome :)

I'm sorry to hear about your sister in law's diagnosis but it is wonderful that you are trying to do something to help her.

I'm afraid I'm not very up on epilepsy drugs and lupus but am rather surprised by that statement :eek: that lupus can't be treated if one has epilepsy. I'm quite sure we have a few members here who have epilepsy and who are treated quite satisfactorily for both.

One thing I'm wondering here is - is it her GP who diagnosed her with lupus? That is pretty unusual as GPs simply don't have the specialised knowledge to deal with lupus. It is a highly complex disease and needs very specialised follow up.

I would say that your sister urgently needs to see an experienced rheumatologist who could best advise what the next step should be. If you need recommendations in your area, you can post here in the find a doctor section.

I hope that others with more drug/epilepsy experience will be along soon to help, bye for now,

Katharine
 

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Welcome to the forum John :)


I guess you are in the UK, as elsewhere a GP would not be prescribing for lupus and I suppose your sister-in-law's lupus has been diagnosed by a rheumatologist. Possibly the rheumy has suggested the anti malarial drug Plaquenil/hydroxychloroquine, the usual treatment for lupus that's not organ threatening.

However the antimalarial drugs can lower the seizure threshold so they need to be prescribed with caution in people with epilepsy. The dose of the Epilim may have to be adjusted as the chloroquines can change the metabolism of the Epilim/valproate.
Consultation between your sister-in-law's neurologist and the rheumatologist with the GP would be best.

This is the only thing I can think of and I could be way off the mark.
I know there are people here with lupus who take Epilim as well as their lupus drugs and who might take Plaquenil too.
A separate post on medications section, with the title "Epilim/valproate & Plaquenil interaction ?" might get some detailed response from those people.

I hope you can get something worked out - it might take a lot of pushing and persistence.

All the best - let us know how it goes please and say Hi to your SIL :)

Bye for now

Clare
 

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Hi,

I agree it's best to get the Rheumatologist and Neurologist together in consultation about this, the Rheumy being the first port of call as he would be the one prescribing Plaquenil.

Plaquenil may lower the seizure threshold as Clare mentioned however some of us take both, it's a matter of fine tuning dosages and close monitoring. Also as with all interactions, it's not a given, it might not interfere at all, it's stated on the drug information that it may interfere. But that doesn't mean the two can't be taken together, it's just something to be mindful of.

love
Lily
 
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