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Discussion Starter · #1 ·
Is this test important in diagnosing SLE?

I am negative for ENA, but not sure what this test really signifies!

Hugs!

Lesley
 

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Hi Lesley,

Of the seven tests included in this panel of tests only one is specific for SLE and that is Sm. Ro can be positive in SLE (and often is in SCLE) but also in Sjogrens. The other 5 can point to other connective tissue diseases. But as we always say ;) the disease is the symptoms...........in the case of your question then someone with say low levles of RNP could have Lupus (rather than MCTD where you would expect high RNP)and there are crossovers of diseases where a patient may have Lupus and Polymyositis or say Lupus and RA etc.

http://www.rcpamanual.edu.au/sections/pathologytest.asp?s=33&i=835

Hope this helps and doesn't confuse :hehe:

love
Lily
 

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Discussion Starter · #3 ·
It does not take much to confuse me at all!

I only asked this question as my dermy keeps harping on that because I'm negative I dont have confirmed Lupus!

I have all but major organ symtoms and anti ds-dna positive though - which is why my Immunologist confirmed dignoses!

This does not help my confusion just add to it!

Thanks!

Lesley
 

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Tell your Dermy to go take a flying leap :rotfl:.........................straight back to medical school preferably ;)

I don't have them either, nor do I have Anti-DsDNA but I have positive ANA, low C3 & C4 when flaring, loads of clinical signs and symptoms, kidney problems and proof via MRA of CNSV, that was enough for them and so it should be :p Where does your Dermy think your DsDNA comes from :rolleyes:

Anti Sm antibodies are not very common yet very specific for SLE. Ro is more common but not everyone has them and depending on symptoms one could have Sjogrens rather than Lupus if Ro was positive.

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Lily
 

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Discussion Starter · #5 ·
Lily,

Yes I have those C3 & C4's too - how can I forget!

My dermies not experienced at all with Lupus (never had one patient until me).

Although her hang-up about the ENA does bug me lots! I cant complain about her too much as she has referred me to a Photobiologist Specialist as St Thoms for my photosentive rashes! She wants them to find out what levels of light cause me problems so that I can treat my skin accordingly.

Not many people get this level of care/expense for this reason paid for by the NHS!

Lesley
 
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