Hi, Yes I had to stop Imuran because it elevated my liver enzymes. I had been on it for several years and it seemed to help. I stopped cold turkey due to Rhumy's advice. Please check with your Doctor before stopping it completely. I now take Cellcept......wish I were still on Imuran(less side-effects) The 6 weeks between stopping Immuran and starting Cellcept,my fatique got much worse. Take care, Rosie