Hi all. I didn't take my weekly MTX injection on Sunday because I've started Imuran. The RD said I was going to get worse before I get better because it takes time for the Imuran to kick in, just like it did with the MTX and the Plaquenil. I've read that it can take several months but I'd like to hear from the Imuran veterans here. How long was it before you started to feel its benefits? It's only 24 hours since I missed my MTX dose and I'm in a world of hurt already. I'm not looking forward to months of feeling like this.