Hi! I've been on Imuran nearly three months now in an attempt to get off of MTX and its side effects. I've been able to cut back on the MTX and hope to stop it completely next week. When I first started Imuran I felt queasy and lost three pounds right away (good!). My appetite continues to be a bit suppressed now that it has kicked in and I've lost another three pounds. I needed to lose this weight so it's not a problem. I don't expect to have any problems maintaining my current weight, I still like to eat, just not as much. I did a search and found that Imuran can cause anorexia. Do any of you have any experience with this or with weight loss in general from Imuran? Right now I don't think it's a problem worth calling my RD about and can wait until my next appointment in a month, but I wanted to run it by you guys and see what you think. Thanks.