Hi All
Thanks for the extra replies and questions.
Claire...The Hosptial Pharmacy gave me a months worth of tabs 100mg per day , everyday.
I have just come back from the doctors for a repeat and she has printed off a letter from the Rhumie for 300mg a day
.
This a copy of the letter
Diagnosis S.L.E.
Medication Change: Introduce Mepacrine 100mg OD wiht a view to increasing by 100mg OD at monthly intervals up to 399mg OD.
Lab tests 27/5/08 Hb 11.6 WBC 7.4, Platelets 266, ESR 27, Creatinine an Electrolytes normal, LFT's normal, CRP >1, Autoimmune profile awaited.
Plan : For trial of aditional Mepacrine treatment after discussion with patient. To introduce slowly as being added to Hydroxychloroquine. For monthly monitoring blood tests. Clinic review in three to four months time.
I saw this lady for review today. She continues to be troubled by variable fatigue and some vague rheumatic pains. The fatigue she continues to find unacceptable. We have discussed the possibiliity of her going onto additional Mepacrine therapy, which is sometimes used. It is about balancing potential benefits versus risks. Although I am not at all convinced that adding in the treatment will make a significant difference in this lady, there is only one way of knowing and that is by giving it a trial and I have therefore commenced it today with a view to it being gradually increased over the next three months, subject to tolerance both clinically and on laboratory testing.

Ok so I feel better and Im in my 2 week of taking it.
What about the dose ( Recommendation from St Thomas was 3 time a week!).
Feels as if this Rhumie is going to OD me ?
No signs yet of yellowing
What does anyone else think about the dose..
He is a stinker for non belief in it helping
Any thoughts?
NIcky
Thanks for the extra replies and questions.
Claire...The Hosptial Pharmacy gave me a months worth of tabs 100mg per day , everyday.
I have just come back from the doctors for a repeat and she has printed off a letter from the Rhumie for 300mg a day
This a copy of the letter
Diagnosis S.L.E.
Medication Change: Introduce Mepacrine 100mg OD wiht a view to increasing by 100mg OD at monthly intervals up to 399mg OD.
Lab tests 27/5/08 Hb 11.6 WBC 7.4, Platelets 266, ESR 27, Creatinine an Electrolytes normal, LFT's normal, CRP >1, Autoimmune profile awaited.
Plan : For trial of aditional Mepacrine treatment after discussion with patient. To introduce slowly as being added to Hydroxychloroquine. For monthly monitoring blood tests. Clinic review in three to four months time.
I saw this lady for review today. She continues to be troubled by variable fatigue and some vague rheumatic pains. The fatigue she continues to find unacceptable. We have discussed the possibiliity of her going onto additional Mepacrine therapy, which is sometimes used. It is about balancing potential benefits versus risks. Although I am not at all convinced that adding in the treatment will make a significant difference in this lady, there is only one way of knowing and that is by giving it a trial and I have therefore commenced it today with a view to it being gradually increased over the next three months, subject to tolerance both clinically and on laboratory testing.
Ok so I feel better and Im in my 2 week of taking it.
What about the dose ( Recommendation from St Thomas was 3 time a week!).
Feels as if this Rhumie is going to OD me ?
No signs yet of yellowing
What does anyone else think about the dose..
He is a stinker for non belief in it helping
Any thoughts?
NIcky