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I recently started taking Methotrexate, I take mine Friday night after dinner with an extra folic acid tab for a total of 4, I take 3 on the other days. Like you I work and thought friday would be good in case I had some side effects. For the first couple of doses I felt tired but it wasn't too bad. My doc started me on 3 (2.5 mg) tabs. I hope the med works well for you, take care
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