Hi Rich, I take 2 or 3 pills a week, depending on how severe my symtoms are. They have greatly helped me. I know when I'm getting due for my dose because my pain increases as the methotrexate loses its power. It has definitely helped me. I use it in conjuction with Humira injections, plaquenil, Relafen, Keflex, and many more. But I think the combination of metho, Humira and plaquenil is helping me get through this.