Hello everybody... i have been taking methotrexate for a few years, before that it was immuran. Imuran didnt do much for me, then cellcept which for me made me sick, and when i started methotrexate (injections) it was a miracle! felt great till the last few months.. been getting so sick from the injections.. for at least a day sometimes two days curled up in a ball so nauseous.. and worst of all getting rashes again and soreness and all that fun stuff Is the nausea quite normal? was i just lucky all these years? have any of you found it stops working after a certain amount of time?