I've been on MTX for about 9-10 weeks and for the past 2 weeks I am at 12.5mg. I took my dose on Friday and the last two days, I've been feeling better. By the end of the day I tired and sore but all of a sudden I feel like it is working. I have a horrible cough so I can't tell completely but would it be all of a sudden like this that a switch goes on and I feel better. Does that make sense?