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Yes, lupus tends to respond well to mtx. I've been on mtx for 17 years and would not be anywhere near where I am without it. I can't handle prednisone above 5 mgs and the mtx has been our best solution on dealing with the sle. Once you get past 15 mgs, ask your rheumy if you should be taking folic acid supplements daily and using leucovorin calcium as a rescue. The purpose of using a rescue is to stop the damage of healthy tissue by the mtx.

Take care of yourself in the 48 hours post mtx. You may find more tenderness and stiffness in this time.

Don't let any infections get a good hold. Because your immune system is suppressed, you may find it takes longer to get over an infection than it did before lupus.
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