My doctor started me on Plaquenil when I was first diagnosed with lupus.
I took 2 tablets each day, and from what I remember it took them a while to start working.
They didn't get rid of my symptoms, but did ease them a bit and I noticed a difference when I stopped taking them.
I took them for about 8 years and didn't have any side effects at the time.
I had regular eye tests because of the medication, but it never affected my eyes.