Hi all,
I've been asked by some to list the 19 possible presentations of Central Nervous System involvement of Lupus. These are recognised by the ACR (American College of Rheumatology) as part of their different criteria used to help diagnosis of CNS Lupus.
Many of you will have read about the 2 official ones that are included in the ACR Criteria which are Psychosis and Central Nervous System Vasculitis (this one comes under the umbrella of Cerebrovascular Disease in the list below).
Because of the variation in criteria the College have case definitions, reporting standards, and diagnostic and testing recommendations of the 19 neuropsychiatric SLE syndromes.
Good Neuro's should be aware of these if they have kept up to date.
The 19 possibles surprised me as some I would never have thought of as being possibly linked to Lupus. I had a fairly obscure first presentation of a movement disorder and an unusual one at that. Chorea is the more likely movement disorder found with SLE, but I first manifested with Dystonia as one of my symptoms.
I think it's helpful to be aware of these presentations especially if you are seeing a Neuro and they are unsure what the reason for your presentation may be.
Acute Inflammatory Demylinating Polyradiculoneuropathy (Guillain-Barre' Syndrome)
Aseptic Meningitis
Autonomic Disorder
Cerebrovascular Disease -. Neurologic deficits from arterial occlusion, venous occlusive disease or haemorrhage, e.g. stroke syndrome, TIA, crhonic multifocal disease, subarachnoid and intracranial haemorrhage, sinus thrombosis
Demylinating Syndrome
Headache : Migraine, tension, cluster, headache from intracranial hypertension, intractable headache nonspecific
Mononeuropathy (single/multiplex)
Movement disorder - most common is Chorea
Myasthenia Gravis
Myelopathy
Neuropathy - Cranial
Plexopathy
Polyneuropathy
Seizures and Seizure disorders
Acute Confusional State
Anxiety Disorder
Cognitive Dysfunction
Mood disorders
Psychosis
The Neuropsychiatric manifestations of SLE are varied and may be classified as primary neurologic & psychiatric disease. Primary (e.g. related to direct involvement of the central nervous system), and secondary disease (e.g. related to complications of the disease and it's treatment). The latter are much more common and can be produced by a variety of mechanisms.
love
Lily
I've been asked by some to list the 19 possible presentations of Central Nervous System involvement of Lupus. These are recognised by the ACR (American College of Rheumatology) as part of their different criteria used to help diagnosis of CNS Lupus.
Many of you will have read about the 2 official ones that are included in the ACR Criteria which are Psychosis and Central Nervous System Vasculitis (this one comes under the umbrella of Cerebrovascular Disease in the list below).
Because of the variation in criteria the College have case definitions, reporting standards, and diagnostic and testing recommendations of the 19 neuropsychiatric SLE syndromes.
Good Neuro's should be aware of these if they have kept up to date.
The 19 possibles surprised me as some I would never have thought of as being possibly linked to Lupus. I had a fairly obscure first presentation of a movement disorder and an unusual one at that. Chorea is the more likely movement disorder found with SLE, but I first manifested with Dystonia as one of my symptoms.
I think it's helpful to be aware of these presentations especially if you are seeing a Neuro and they are unsure what the reason for your presentation may be.
Acute Inflammatory Demylinating Polyradiculoneuropathy (Guillain-Barre' Syndrome)
Aseptic Meningitis
Autonomic Disorder
Cerebrovascular Disease -. Neurologic deficits from arterial occlusion, venous occlusive disease or haemorrhage, e.g. stroke syndrome, TIA, crhonic multifocal disease, subarachnoid and intracranial haemorrhage, sinus thrombosis
Demylinating Syndrome
Headache : Migraine, tension, cluster, headache from intracranial hypertension, intractable headache nonspecific
Mononeuropathy (single/multiplex)
Movement disorder - most common is Chorea
Myasthenia Gravis
Myelopathy
Neuropathy - Cranial
Plexopathy
Polyneuropathy
Seizures and Seizure disorders
Acute Confusional State
Anxiety Disorder
Cognitive Dysfunction
Mood disorders
Psychosis
The Neuropsychiatric manifestations of SLE are varied and may be classified as primary neurologic & psychiatric disease. Primary (e.g. related to direct involvement of the central nervous system), and secondary disease (e.g. related to complications of the disease and it's treatment). The latter are much more common and can be produced by a variety of mechanisms.
love
Lily