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6 weeks is long enough to set off a flare. Plaquenil does stay in your system awhile but I think it is 28 days or so which is a long time for a drug to remain. I would call your doctor tomorrow if you can and let him know exactly what is going on. He may want to put you on a short course of steroids and put you back on the Plaquenil. Please don't wait until the end of the month, the sooner you start getting it under control the sooner you will start to feel better. Also the longer you go the greater your chances are that the lupus could affect a new area of your body.

Let us know what happens,
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