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Plaquenil usually has the opposite effect initially !
It's best to use dietary changes rather than a laxative, although I don't know exactly what it is you are taking. Drink plenty, more roughage/fibre prune juice or prunes all the usual stuff, cut out white flour products. I notice at once if I don't have my daily salad with dressing and fruit. I once made some bran blueberry muffins which were very delicious so I ate several .......... never to be forgotten. I once had whole raw oats for breakfast with the same drastic effect.

If you have started on 400mgs a day, try cutting back to 200mgs to give your system a chance to adapt and hopefully ease these symptoms.

Good luck!

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