I have only just started to take Plaquenil on Thursday (I was diagnosed in Nov last year) and now have terrible indigestion and feel slight nauseous. I'm also taking amitriptyline at night to help me get a better nights sleep. Has anyone else had these problems on Plaquenil and did they get better after taking the medication for a while? I don't want to stop taking them as I hope it will help with my joint pain and tiredness. Thanks in advance for any help. Hope everyone is having a good day.