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I have taken both the Brand name and Generic 200 mg twice a day. I take the Generic now and don't have any trouble with it. It did upset my tummy for the first couple 2-3 weeks but I was only taking it with milk. The pharmacist told me to try taking it with a meal (after getting something more substantial in my stomach) and that helped a lot. The Plaquenil helped with my joint aches/pain and fatigue within about 6 weeks. I went off of it about year or so ago and flared terribly so went right back on it. It really does help me!

Nancy
 
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