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Hi everyone

I had my first appointment with the rheumatologist this week. I have been prescribed Mepacrine (1/2 tablet 3 times a week).

Can anyone advise me on how long it takes to make a difference to joint pain/profound fatigue problems? (I have previously tried Chloroquine and Hydroxychloroquine (Plaquenil) with no success).

Thanks.
 

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Hello lincs lass

Mepacrine ( US Quinacrine) acts within one or two months compared with about 3-6 months for Plaquenil. ( Source Dr D Wallace Dubois)

I suggest asking your doctor about taking it along with either chloroquine or Plaquenil. They work together, each enhancing the effects of the other, 'synergistically' as they call it.
I have taken 400mgs Plaquenil, replaced for the last 10 years or so with 500 mgs chloroquine, along with 100mgs a day Mepacrine. I found the addition of the Mepacrine completely eased my arthritis and was very energising, also made a remarkable improvement in skin

I know that UK doctors are much more conservative with their dosing, however the doc at St Thomas' was happy for me to continue on this regime

All the best :)
Clare
 

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Lincs lass, Mepacrine is a good medication. My Daughter and I take it as we are allergic to Plaquenil. My Daughter has only been taking it for a month or so and has already noticed a difference in her stamina.

Horrible taste though isn't it?
x Lola

If you have skin problems , it is very beneficial.
 

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Hi

Made a difference in energy levels within 3 months
Tastes horrible!

A highly beneficial drug but unfortunately I got a drug allergy of lichen planus and had to come off of it.

I would recommend it for benefits still:) other than the allergy of course!

Nicky
 
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