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Text from the following article concerning Rituxan:

http://emedicine.medscape.com/article/335186-treatment?src=emed_whatnew_nl_0#Rituximab


Rituximab (Rituxan), a monoclonal antibody that inhibits CD20 antigen on B lymphocytes, is currently a Pregnancy Category C medication. Rituximab is indicated for the treatment for moderate to severe RA.38 Case reports on the use of rituximab during pregnancy have been reported in the oncology literature.39,40,41,42 Case reports have also shown that rituximab therapy results in detectable levels of the drug in cord blood and results in B-cell depletion in both mother and neonate.43,44 Recovery of B-cell levels in the neonate has been reported to occur at age 3-4 months and does not appear to impair antibody formation to immunizations.43,44 The dosing of rituximab in case reports was 375 mg/m2 in 1-6 cycles.44,39 Although it is unknown whether rituximab is excreted in human milk, IgG is present in human milk, and rituximab has been detected in the milk of monkeys.38
 
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