Hello Nicky
I am sure the idea of stopping the Plaquenil is very worrying
I daresay the dermy thinks everything has to be tried to get the LP under control. I have no idea how much the Plaquenil might be contributing to the LP.
About the Mepacrine dose you were on, I recall us deciding that the 300 mgs a day the rheumy suggested was far too much, since the maximum recommended by Dr Wallace is not above 100 mgs a day. Dr Wallace mentions staying on this as a therapeutic dose for 3-6 months then reducing to a maintenance dose.
I know that St Thomas often suggests taking Mepacrine 2 or 3 times a week. They were happy for me to stay on the 100mgs a day that I have been on for years
I'd say the combination is perfectly 'good practice', but it's not well known. It was forgottten about when Plaquenil replaced Mepacrine commercially for antimalarial prevention. If there was any significant problem with the combination it wouldn't be used by leading lupologists and we would know all about any associated warnings.
I think you have been very, very unlucky and I feel gutted for you.
Dr Wallace says that of 120,000 troops, 2,000 got rashes, mainly dermatitis A dermatologist would usually defer to a rheumatologist for overall lupus treatment, I'd guess Imuran or methotrexate.
Many Hugs
Clare
I am sure the idea of stopping the Plaquenil is very worrying
About the Mepacrine dose you were on, I recall us deciding that the 300 mgs a day the rheumy suggested was far too much, since the maximum recommended by Dr Wallace is not above 100 mgs a day. Dr Wallace mentions staying on this as a therapeutic dose for 3-6 months then reducing to a maintenance dose.
I know that St Thomas often suggests taking Mepacrine 2 or 3 times a week. They were happy for me to stay on the 100mgs a day that I have been on for years
I'd say the combination is perfectly 'good practice', but it's not well known. It was forgottten about when Plaquenil replaced Mepacrine commercially for antimalarial prevention. If there was any significant problem with the combination it wouldn't be used by leading lupologists and we would know all about any associated warnings.
I think you have been very, very unlucky and I feel gutted for you.
Dr Wallace says that of 120,000 troops, 2,000 got rashes, mainly dermatitis A dermatologist would usually defer to a rheumatologist for overall lupus treatment, I'd guess Imuran or methotrexate.
Many Hugs
Clare