Hi everyone, my daughter has lupus and I have a question about swelling. Her hand, knees, legs, feet and ankles swell so bad that she has to go to bed, they are also painful. She is taking plaquinell, and 25mg of inuram (she was taking 50mg but it make her feel bad tired and she feels better on the 25mg, she has been on it for over three months now) I don't think the inuram is going anything at all. She has an appointment with the doctor next week and I told her to talk to him about trying something else. Could you please let me know if anyone else has these same problems and what they take for it. She has not fever or headache this time with the swelling. She also takes a water pill everyday. Thanks hope you have a wonderful day..... also I forgot she gets the brain fog also she takes blood thinner so can not take some medicines.