It seems like one of the big pointers for autoimmune disease is weight loss rather than weight gain, but I seem to be gaining. I'm still being assessed by both neurologists and rheumies for a variety of symptoms. I have a strong family history of autoimmune disorders, the classic malar rash, what looks like livedo reticularis, and various other lupus like symptoms. In the past, I was diagnosed with coeliac disease (another autoimmune thing) about 10 years ago, and rather than having weight loss with that, again I gained a lot of weight, which dropped off me again once I was diagnosed and went on the gluten free diet. Now again I am gaining weight fairly rapidly as I go through yet another flare of this mysterious illness. I thought it might be fluid, but went to GP who said it was just wind that was making my belly so much fatter (waist measurement increased 4 inches in a couple of months). My face also feels like it is swelling, particularly after lying down in bed at night, but my ankles aren't swollen. I'm not particularly active due to mobility problems, but do move around as much as possible, and I'm hardly eating much at all due to continual GI problems (dificulty swallowing, feeling full really quickly, nausea, etc). From my much reduced calorie intake I should be losing at least a pound if not two a week, but I'm not losing anything at all. What confuses me is that everything is saying that I should be losing weight, rather than gaining, and thats not the case. Can anyone offer any explanations?