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Hi G!
I have been on plaquenil since June of 07. I have to say I am just now starting to feel its effects at 400 mg. I was put on prednisone as well in the interim for skin involvement. My Rheumy has not seen the results as he had hoped (skin still a mess - though not as bad) and has added methotrexate. I agree with the others, I'd say 7-9+ months for benefits.
Hope it works for you!
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